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NBM-T-BMX-OS01

CAT: 0931-T210805-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210805-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1246952-34-0
Target
VEGFR, Akt, FAK, PERK
Related Pathways
Angiogenesis, PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, Apoptosis
Bioactivity
NBM-T-BMX-OS01 is a derivative of Osthole. It can inhibit the phosphorylation of VEGFR2, FAK, Akt, and ERK, demonstrating anti-angiogenic activity. Additionally, NBM-T-BMX-OS01 exhibits anticancer properties against colorectal cancer.
Smiles
O(CC1=CC=C(OC)C=C1)C2=C(CC=C(C)C)C(OC)=CC=C2/C=C/C(NO)=O
Molecular Formula
C23H27NO5
Molecular Weight
397.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

NBM-T-L-BMX-OS01 (bmx)

HDAC8 Inhibitor NBM-BMX is an orally bioavailable inhibitor of histone deacetylase (HDAC) type 8 (HDAC8; HDAC-8), with potential antineoplastic activity. Upon administration, NBM-BMX targets and inhibits the activity of HDAC8. This results in an accumulation of highly acetylated chromatin histones, chromatin remodeling, and selective transcription of tumor suppressor genes, ultimately promoting cell-cycle arrest and induction of tumor cell apoptosis. HDAC8, a class 1 histone deacetylase, plays a key role in transcriptional regulation and cell cycle progression. Aberrant expression of HDAC8 or deregulated interactions with transcription factors may contribute to tumorigenesis. Isotype-selective HDAC inhibitors may be associated with fewer adverse effects compared to pan-HDAC inhibitors.

CAS Number1246952-34-0
PubChem CID46931326
IUPAC Name(E)-N-hydroxy-3-[4-methoxy-2-[(4-methoxyphenyl)methoxy]-3-(3-methylbut-2-enyl)phenyl]prop-2-enamide
Molecular FormulaC23H27NO5
Molecular Weight397.5
XLogP4.5
Topological Polar Surface Area77
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Heavy Atom Count29
Formal Charge0
Complexity549
SMILES
CC(=CCC1=C(C=CC(=C1OCC2=CC=C(C=C2)OC)/C=C/C(=O)NO)OC)C
InChI
InChI=1S/C23H27NO5/c1-16(2)5-12-20-21(28-4)13-8-18(9-14-22(25)24-26)23(20)29-15-17-6-10-19(27-3)11-7-17/h5-11,13-14,26H,12,15H2,1-4H3,(H,24,25)/b14-9+
InChIKey
SOWOYQPLOHLYEY-NTEUORMPSA-N
Chemical Structure
2D Structure
2D structure of NBM-T-L-BMX-OS01 (bmx)
CAS: 1246952-34-0
CID: 46931326
Formula: C23H27NO5
MW: 397.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight397.5
XLogP34.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Exact Mass397.18892296
Monoisotopic Mass397.18892296
Topological Polar Surface Area77 Ų
Heavy Atom Count29
Formal Charge0
Complexity549
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
GTR19263314-01NBM-T-BMX-OS01
308054BMX
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GTR18898248-01BMX peptide
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