Antitrypanosomal agent 26

• Target:

  Parasite

• Related Pathways:

  Microbiology/Virology

• Bioactivity:

  Antitrypanosomal agent 26 (Compound 1) is an allosteric inhibitor of trypanosome alternative oxidase (TAO) . It exhibits potent activity against African trypanosomes, such as Trypanosoma brucei, with an IC50 value of 1.3 nM for recombinant TAO. The compound disrupts the mitochondrial electron transport chain of trypanosomes and inhibits glucose-dependent respiration. Antitrypanosomal agent 26 shows potential for research in treating African animal trypanosomiasis, including bovine trypanosomiasis.

• Smiles:

  [Br-].O=C (OCCCCCCCCCCCCCC[P+] (C1=NC=CC=C1) (C=2C=CC=CC2) C=3C=CC=CC3) C4=CC=C (O) C=C4C

• Molecular Formula:

  C39H49BrNO3P

• Molecular Weight:

  690.69

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2601665-22-7