BT-O2C

• Target:

  Histone Acetyltransferase|||PROTACs|||Epigenetic Reader Domain

• Related Pathways:

  PROTAC|||Chromatin/Epigenetic

• Bioactivity:

  BT-O2C is a highly selective p300 PROTAC degrader that effectively reduces p300 levels in HAP1 cells. It exhibits significant cytotoxicity in CIC:DUX4 sarcoma (CDS) cell lines, with an IC50 of 152-221 nM, and notably decreases the expression of CDS target genes (ETV1, ETV4, ETV5) . BT-O2C is applicable in cancer research.

• Smiles:

  O=C1[C@]2(C=3C([C@H](F)C2)=CC(=CC3)C4=CN(CC(NCCCCCCCNC=5C=C6C(=CC5)C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=O)N=C4)NC(=O)N1CC(N(CC8=CC=C(F)C=C8)[C@H](C(F)(F)F)C)=O

• Molecular Formula:

  C48H48F5N9O8

• Molecular Weight:

  973.94

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3055107-34-8