BT-O2C

• Target:

  Histone Acetyltransferase|||PROTACs|||Epigenetic Reader Domain

• Related Pathways:

  PROTAC|||Chromatin/Epigenetic

• Bioactivity:

  BT-O2C is a highly selective p300 PROTAC degrader that effectively reduces p300 levels in HAP1 cells. It exhibits significant cytotoxicity in CIC:DUX4 sarcoma (CDS) cell lines, with an IC50 of 152-221 nM, and notably decreases the expression of CDS target genes (ETV1, ETV4, ETV5) . BT-O2C is applicable in cancer research.

• Smiles:

  O=C1[C@]2 (C=3C ([C@H] (F) C2) =CC (=CC3) C4=CN (CC (NCCCCCCCNC=5C=C6C (=CC5) C (=O) N (C6=O) C7C (=O) NC (=O) CC7) =O) N=C4) NC (=O) N1CC (N (CC8=CC=C (F) C=C8) [C@H] (C (F) (F) F) C) =O

• Molecular Formula:

  C48H48F5N9O8

• Molecular Weight:

  973.94

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3055107-34-8