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PI3Kδ-IN-21

CAT: 0931-T209858-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T209858-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PI3K
Related Pathways
PI3K/Akt/mTOR signaling
Bioactivity
PI3Kδ-IN-21 (Compound 31) is a selective inhibitor of phosphoinositide 3-kinase δ (PI3Kδ), with an IC50 of 13.6 nM. It impedes the proliferation and differentiation of T cells through the PI3K/AKT/mTOR signaling pathway. In rat models, PI3Kδ-IN-21 exhibits favorable pharmacokinetic properties and demonstrates activity in improving experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein (MOG) in EAE models.
Molecular Formula
C19H16ClN9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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