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Antiproliferative agent-49

CAT: 0931-T209337-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T209337-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, EGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling, Apoptosis
Bioactivity
Antiproliferative agent-49 (Compound 5a) is an EGFR-TK inhibitor with an IC50 of 0.09 μM and serves as an antiproliferative agent. It exhibits significant activity against HER3 and HER4, with IC50 values of 0.18 and 0.37 μM, respectively. Additionally, Antiproliferative agent-49 triggers the mitochondrial apoptotic pathway and enhances ROS accumulation.
Molecular Formula
C22H18N2O2S
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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