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AXL-IN-13

CAT: 0931-T73300-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T73300-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2376928-82-2
Target
FLT, PDGFR, TAM Receptor, TGF-beta/Smad
Related Pathways
Tyrosine Kinase/Adaptors, Stem Cells, Angiogenesis
Purity
0.9995
Bioactivity
AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 of 1.6 nM and a Kd of 0.26 nM. It exhibits anticancer activity, reverses TGF-β1-induced epithelial-mesenchymal transition (EMT), and inhibits cancer cell migration and invasion.
Smiles
O(C=1C2=C(C=C(OCCCN3CCOCC3)C(OC)=C2)N=CC1)C4=C(F)C=C(NC=5C(C(NC6CCCCC6)=O)=CN(C)N5)C=C4
Molecular Formula
C34H41FN6O5
Molecular Weight
632.72
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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