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Ki11502

CAT: 0931-T208725-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T208725-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
347155-76-4
Target
Akt, Bcl-2 Family, Apoptosis, FLT, PERK, PDGFR
Related Pathways
Cytoskeletal Signaling, Apoptosis, Tyrosine Kinase/Adaptors, Angiogenesis, PI3K/Akt/mTOR signaling
Bioactivity
Ki11502 is a multi-target receptor tyrosine kinase (RTK) inhibitor that selectively inhibits the activity of PDGFβ/α receptors (with an IC50 of less than 10 nM) . It specifically suppresses PDGFβ receptor phosphorylation, proliferation, and proteoglycan synthesis in human vascular smooth muscle cells. Additionally, Ki11502 induces apoptosis and exhibits significant antiproliferative effects against specific leukemia subgroups, including those with Imatinib-resistant mutations. It is particularly suitable for studying the role of PDGF in vascular diseases and the involvement of proteoglycans in atherosclerosis.
Smiles
O=C(NC(=S)NC1=CC=C(OC=2C=CN=C3C=C(OC)C(OC)=CC32)C=C1)C=4C=CC=CC4C
Molecular Formula
C26H23N3O4S
Molecular Weight
473.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Ki-11502

Ki11502 is a member of the class of quinolines that acts as a receptor tyrosine kinase inhibitor and apoptosis inducer with potential for use in treatment of leukemia and colorectal cancer. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an apoptosis inducer. It is a member of benzamides, a member of quinolines, an aromatic ether and a member of thioureas.

CAS Number347155-76-4
PubChem CID11554659
IUPAC NameN-[[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]carbamothioyl]-2-methylbenzamide
Molecular FormulaC26H23N3O4S
Molecular Weight473.5
XLogP5.6
Topological Polar Surface Area114
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count34
Formal Charge0
Complexity687
SMILES
CC1=CC=CC=C1C(=O)NC(=S)NC2=CC=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC
InChI
InChI=1S/C26H23N3O4S/c1-16-6-4-5-7-19(16)25(30)29-26(34)28-17-8-10-18(11-9-17)33-22-12-13-27-21-15-24(32-3)23(31-2)14-20(21)22/h4-15H,1-3H3,(H2,28,29,30,34)
InChIKey
ZXGIBSBJQLLUEE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ki-11502
CAS: 347155-76-4
CID: 11554659
Formula: C26H23N3O4S
MW: 473.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight473.5
XLogP35.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass473.14092740
Monoisotopic Mass473.14092740
Topological Polar Surface Area114 Ų
Heavy Atom Count34
Formal Charge0
Complexity687
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-112417-01Ki11502

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