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Ki11502

CAT: 0013-GTR19261494-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19261494-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ki11502 is a multi-target receptor tyrosine kinase (RTK) inhibitor that selectively inhibits the activity of PDGFβ/α receptors (with an IC50 of less than 10 nM) . It specifically suppresses PDGFβ receptor phosphorylation, proliferation, and proteoglycan synthesis in human vascular smooth muscle cells. Additionally, Ki11502 induces apoptosis and exhibits significant antiproliferative effects against specific leukemia subgroups, including those with Imatinib-resistant mutations. It is particularly suitable for studying the role of PDGF in vascular diseases and the involvement of proteoglycans in atherosclerosis.
CAS Number
347155-76-4
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
O=C (NC (=S) NC1=CC=C (OC=2C=CN=C3C=C (OC) C (OC) =CC32) C=C1) C=4C=CC=CC4C
Molecular Formula
C26H23N3O4S
Molecular Weight
473.54
Storage Conditions
-20°C
Notes
For research use only.

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CatalogName
HY-112417-01Ki11502

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