Ki11502

CAT: 0931-T208725-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T208725-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

347155-76-4

Target

Akt, Bcl-2 Family, Apoptosis, FLT, PERK, PDGFR

Related Pathways

Cytoskeletal Signaling, Apoptosis, Tyrosine Kinase/Adaptors, Angiogenesis, PI3K/Akt/mTOR signaling

Bioactivity

Ki11502 is a multi-target receptor tyrosine kinase (RTK) inhibitor that selectively inhibits the activity of PDGFβ/α receptors (with an IC50 of less than 10 nM) . It specifically suppresses PDGFβ receptor phosphorylation, proliferation, and proteoglycan synthesis in human vascular smooth muscle cells. Additionally, Ki11502 induces apoptosis and exhibits significant antiproliferative effects against specific leukemia subgroups, including those with Imatinib-resistant mutations. It is particularly suitable for studying the role of PDGF in vascular diseases and the involvement of proteoglycans in atherosclerosis.

Smiles

O=C(NC(=S)NC1=CC=C(OC=2C=CN=C3C=C(OC)C(OC)=CC32)C=C1)C=4C=CC=CC4C

Molecular Formula

C26H23N3O4S

Molecular Weight

473.54

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Alternative Products

Catalog	Name
HY-112417-01	Ki11502

Ki11502

Alternative Products

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