Reveromycin C

• Target:

  Antibacterial

• Related Pathways:

  Microbiology/Virology

• Bioactivity:

  Reveromycin C is a polyketide compound originally isolated from Streptomyces, exhibiting antifungal activity against Candida albicans with a MIC of 2.0 ?g/mL at pH 3 and >500 ?g/mL at pH 7.4. It inhibits EGF-induced mitogenic activity in Balb/MK mouse epidermal cell lines. Additionally, it reverses the morphology of sarcoma virus-transformed NRK rat kidney cells (EC50 = 1.58 ?g/mL) and inhibits the proliferation of KB cells and K562 human chronic myelogenous leukemia cells (IC50 = 2.0 ?g/mL for both) .

• Smiles:

  O(C(CCC(O)=O)=O)[C@@]1(CCC(C)C)[C@H](/C=C/C(=C/C(O)=O)/C)O[C@@]2(CC1)O[C@H](C/C=C(/C=C/[C@@H]([C@H](/C=C/C(O)=O)C)O)\C)[C@@H](C)CC2

• Molecular Formula:

  C37H54O11

• Molecular Weight:

  674.82

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  144860-69-5