Reveromycin A

• Target:

  Others|||Antifungal|||Apoptosis|||Antibiotic

• Related Pathways:

  Apoptosis|||Others|||Microbiology/Virology

• Bioactivity:

  Reveromycin A is the major component of a complex of spiroketal antibiotics isolated from Streptomyces sp. It inhibits the mitogenic activity of epidermal growth factor in Balb/MK cells (IC50 = 0.7 ?g/ml), displays antiproliferative activity against human KB and K562 tumor cell lines (IC50s = 1.9 and 1.6 ?g/ml, respectively), and demonstrates antifungal activity against C. albicans (MIC = 2 ?g/ml at pH 3) . Reveromycin A also has been shown to inhibit bone resorption by inducing apoptosis in osteoclasts with an IC50 value of 0.7 ?M.

• Smiles:

  CCCC[C@]1 (CC[C@]2 (CC[C@H] (C) [C@@H] (C\C=C (/C) \C=C\[C@H] (O) [C@@H] (C) \C=C\C (O) =O) O2) O[C@H]1\C=C\C (\C) =C\C (O) =O) OC (=O) CCC (O) =O

• Molecular Formula:

  C36H52O11

• Molecular Weight:

  660.79

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  134615-37-5