Reveromycin B

• Target:

  Others|||Antibacterial

• Related Pathways:

  Microbiology/Virology|||Others

• Bioactivity:

  Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC50 = 6 ?g/ml) and exhibits pH-dependent antifungal activity against C. albicans [MICs = 15.6 and >500 ?g/ml at pH 3.0 and 7.4, respectively]. Unlike reveromycin A and reveromycin C, reveromycin B does not inhibit the proliferation of KB and K562 cells.

• Smiles:

  CCCC[C@@]1(CC[C@]2(CC[C@H](C)[C@@H](C\C=C(/C)\C=C\[C@H](O)[C@@H](C)\C=C\C(O)=O)O2)O1)[C@@H](OC(=O)CCC(O)=O)\C=C\C(\C)=C\C(O)=O

• Molecular Formula:

  C36H52O11

• Molecular Weight:

  660.79

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  144860-68-4