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JH-RE-06

CAT: 0931-T15611-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T15611-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1361227-90-8
Target
DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Purity
0.9929
Bioactivity
JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ. JH-RE-06 is an effective REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), which targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 also improves chemotherapy.
Smiles
CC(C)CC(=O)c1c(Nc2ccc(Cl)cc2Cl)[nH]c2c(Cl)ccc([N+]([O-])=O)c2c1=O
Molecular Formula
C20H16Cl3N3O4
Molecular Weight
468.72
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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BA3978-10JH-RE-06
A19168-1JH-RE-06 1mg
HY-126214S-01JH-RE-06-d6
A19168-100JH-RE-06 100mg
A19168-25JH-RE-06 25mg
A19168-50JH-RE-06 50mg
A19168-10JH-RE-06 10mg
A19168-5JH-RE-06 5mg
A19168-10mM-DJH-RE-06 10mM * 1mL in DMSO
MBS3607037JH-T4

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