JH-RE-06

• Target :

  DNA/RNA Synthesis

• Related Pathways :

  DNA Damage/DNA Repair|||Cell Cycle/Checkpoint

• Purity :

  0.9929

• Bioactivity :

  JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POL?. JH-RE-06 is an effective REV1-REV7 interface inhibitor (IC50=0.78 ?M; Kd=0.42 ?M), which targets REV1 that interacts with the REV7 subunit of POL?. JH-RE-06 also improves chemotherapy.

• Smiles :

  CC(C)CC(=O)c1c(Nc2ccc(Cl)cc2Cl)[nH]c2c(Cl)ccc([N+]([O-])=O)c2c1=O

• Molecular Formula :

  C20H16Cl3N3O4

• Molecular Weight :

  468.72

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1361227-90-8