JH-RE-06

• Target:

  DNA/RNA Synthesis

• Related Pathways:

  DNA Damage/DNA Repair|||Cell Cycle/Checkpoint

• Purity:

  0.9929

• Bioactivity:

  JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POL?. JH-RE-06 is an effective REV1-REV7 interface inhibitor (IC50=0.78 ?M; Kd=0.42 ?M), which targets REV1 that interacts with the REV7 subunit of POL?. JH-RE-06 also improves chemotherapy.

• Smiles:

  CC(C)CC(=O)c1c(Nc2ccc(Cl)cc2Cl)[nH]c2c(Cl)ccc([N+]([O-])=O)c2c1=O

• Molecular Formula:

  C20H16Cl3N3O4

• Molecular Weight:

  468.72

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1361227-90-8