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12-Nitrolinoleate

CAT: 0931-T207754-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207754-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
774603-05-3
Target
Others, Interleukin, PPAR, NF-κB, TNF
Related Pathways
Apoptosis, Immunology/Inflammation, NF-κB, Metabolism, Others, DNA Damage/DNA Repair
Bioactivity
12-Nitrolinoleate is a linoleic acid derivative that acts as an agonist of peroxisome proliferator-activated receptor γ (PPARγ) . Formed via exposure to acidified nitrite, it is present in human red blood cells and plasma. This compound stimulates PPARγ-dependent gene expression, demonstrated in a reporter assay with MCF-7 cells expressing human PPARγ, with an EC50 of 0.045 μM. At 2.5 μM, 12-Nitrolinoleate reduces the secretion of IL-6, TNF-α, and chemokine (C-C motif) ligand 2 (CCL2) in THP-1 and RAW 264.7 macrophages, and it suppresses LPS-induced NF-κB transcriptional activity in RAW 264.7 macrophages. Additionally, it inhibits TNF-α-induced increases in vascular cell adhesion molecule-1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs) and enhances heme oxygenase-1 (HO-1) levels in primary human aortic endothelial cells at concentrations of 1, 5, or 10 μM.
Smiles
C(\C/C=C\CCCCCCCC(O)=O)(=C\CCCCC)/N(=O)=O
Molecular Formula
C18H31NO4
Molecular Weight
325.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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