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PLD1 Inhibitor

CAT: 0931-T207752-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207752-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1001957-60-3
Target
Others
Related Pathways
Others
Bioactivity
PLD1 inhibitor is a compound that targets phospholipase D1 (PLD1) . It suppresses PLD activity in A549 cells overexpressing PLD1 with an IC50 of 1.97 μM. This inhibitor also decreases the viability of A549 lung cancer and HCT116 colorectal cancer cells, with IC50 values of 18 and 29 μM, respectively. Furthermore, it impairs proliferation, migration, and invasion of A549 cells and triggers apoptosis. Administered at 10 mg/kg every other day, PLD1 inhibitor diminishes tumor growth, induces intratumoral apoptosis, and lowers levels of Ras, CD47, CD24, and programmed cell death 1 ligand 1 (PD-L1) in a murine Lewis lung carcinoma model.
Smiles
O=C(NC=1C=C(C=C(C1)C(F)(F)F)C(F)(F)F)CCC2=CNC=3C=CC=CC32
Molecular Formula
C19H14F6N2O
Molecular Weight
400.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

1001957-60-3

PubChem
cas1001957-60-3
modify2026-05-17
synonyms
PLD-IN-11001957-60-3orb3027430EX-A13694T2077523 Chemical and Physical Properties3.1 Computed PropertiesProperty Name Property Value ReferenceMolecular Weight400.3 g/mol+ 15 more
PubChem LinkClick here

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