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GLS1 Inhibitor

CAT: 0931-T37222-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T37222-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1832646-52-2
Target
Others, Glutaminase
Related Pathways
Proteases/Proteasome, Others
Bioactivity
GLS1 inhibitor is an inhibitor of glutaminase 1 (GLS1; IC50= 0.021 μM) .1It inhibits the growth of NCI H1703 non-small cell lung cancer (NSCLC) cellsin vitro (GI50= 0.011 μM) . GLS1 inhibitor (100 mg/kg) reduces tumor growth, increases tumor levels of glutamine, and decreases tumor levels of glutamate and aspartate in an NCI H1703 mouse xenograft model.
Smiles
N([C@H]1CN(CC1)C2=CC=CN=N2)C=3SC(NC([C@@H](OC)C4=CC=CC=C4)=O)=NN3
Molecular Formula
C19H21N7O2S
Molecular Weight
411.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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