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PLD1 Inhibitor

CAT: 0013-GTR19258157-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258157-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PLD1 inhibitor is a compound that targets phospholipase D1 (PLD1) . It suppresses PLD activity in A549 cells overexpressing PLD1 with an IC50 of 1.97 μM. This inhibitor also decreases the viability of A549 lung cancer and HCT116 colorectal cancer cells, with IC50 values of 18 and 29 μM, respectively. Furthermore, it impairs proliferation, migration, and invasion of A549 cells and triggers apoptosis. Administered at 10 mg/kg every other day, PLD1 inhibitor diminishes tumor growth, induces intratumoral apoptosis, and lowers levels of Ras, CD47, CD24, and programmed cell death 1 ligand 1 (PD-L1) in a murine Lewis lung carcinoma model.
CAS Number
1001957-60-3
Field of Research
Pharmacology & Drug Discovery; Cell Biology
Smiles
O=C (NC=1C=C (C=C (C1) C (F) (F) F) C (F) (F) F) CCC2=CNC=3C=CC=CC32
Molecular Formula
C19H14F6N2O
Molecular Weight
400.32
Storage Conditions
-20°C
Notes
For research use only.

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