TRBP-IN-1

CAT: 0931-T207594-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T207594-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

MicroRNA, DNA/RNA Synthesis, Apoptosis, Pyroptosis

Related Pathways

Chromatin/Epigenetic, Cell Cycle/Checkpoint, Apoptosis, DNA Damage/DNA Repair, Immunology/Inflammation

Bioactivity

TRBP-IN-1 (Compound 13j) is an orally active inhibitor of TAR RNA-binding protein 2 (TRBP) with an IC50 of 12.72 μM. It exhibits significant anti-hepatocellular carcinoma (HCC) activity, effectively suppressing proliferation and metastasis of HCC cells [HCCLM3 cells (IC50: 18.96 μM) and SK-Hep-1 cells (IC50: 16.45 μM) ]. TRBP-IN-1 modulates miRNA biosynthesis by targeting TRBP, inhibiting the expression of oncogenic miRNAs. It induces apoptosis and pyroptosis in HCC cells by decreasing miRNA levels. TRBP-IN-1 is suitable for research on targeted HCC therapy.

Molecular Formula

C25H23F3N2O5S

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-172885	TRBP-IN-1
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