TRBP-IN-1

CAT: 0804-HY-172885Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-172885Size:1 Each
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRBP-IN-1 (Compound 13j) is an orally active TAR RNA binding protein 2 (TRBP) inhibitor (IC50: 12.72 μM) . TRBP-IN-1 has significant anti-hepatocellular carcinoma (HCC) activity and can inhibit the proliferation and metastasis of HCC cells (HCCLM3 cells (IC50: 18.96 μM) ; SK-Hep-1 cells (IC50: 16.45 μM) ) . TRBP-IN-1 regulates miRNA biogenesis and inhibits oncogenic miRNA expression by targeting TRBP. TRBP-IN-1 induces apoptosis and pyroptosis in HCC cells by inhibiting the level of miRNA. TRBP-IN-1 can be used for targeted therapy research of HCC[1].
UNSPSC
12352211
Target
Apoptosis; DNA/RNA Synthesis; MicroRNA; Pyroptosis
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
COC(C1=C(C(OC)=C(C(OC)=C1)OC)C2=CC=C(C=C2)NC(NC3=CC=CC(C(F)(F)F)=C3)=S)=O
Molecular Formula
C25H23F3N2O5S
Molecular Weight
520.52
References & Citations
[1]Zhang R, et al. Structural optimization and pharmacological evaluation of diphenyl amine esters as anti-hepatocellular carcinoma agents by targeting TAR RNA-binding protein 2. Eur J Med Chem. 2025 Jul 5;291:117676.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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