RNA binder 1

CAT: 0013-GTR19257729-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19257729-01Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

RNA binder 1 (Compound 4b) is an RNA-binding agent capable of crossing the blood-brain barrier. It selectively binds to the G-quadruplex structure of the G4C2 repeat sequence RNA of the C9orf72 gene. This compound significantly reduces levels of the toxic polypeptides poly (GA) and poly (GP) in cells derived from amyotrophic lateral sclerosis (ALS) patients, while it has no significant impact on the antisense polypeptide poly (PR), demonstrating selectivity for sense RNA. RNA binder 1 is useful for studying ALS and frontotemporal dementia (FTD) .

Field of Research

Cell Biology, Molecular Biology

Molecular Formula

C22H20N10S2

Storage Conditions

-20°C

Notes

For research use only.

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