PDE4B-IN-4

• Target:

  PDE|||TNF

• Related Pathways:

  Apoptosis|||Metabolism

• Bioactivity:

  PDE4B-IN-4 is an inhibitor of PDE4B (IC50: 2.82 nM) and TNF-? (IC50: 7.20 nM) . It demonstrates anti-inflammatory properties by reducing neutrophilia in a mouse model of lipopolysaccharide (LPS) -induced sepsis.

• Smiles:

  O=C1NC (N/N=C/C2=CC=C (OC) C (OC) =C2) =NC (C3=CC (OC4CCCC4) =C (OC) C=C3) =C1C#N

• Molecular Formula:

  C26H27N5O5

• Molecular Weight:

  489.52

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C