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PDE4B/7A-IN-2

CAT: 0931-T62064-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T62064-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2511632-55-4
Target
Others, PDE
Related Pathways
Others, Metabolism
Bioactivity
This compound is a dual 5-HT1A/5-HT7 receptor antagonist (5-HT1A Ki = 8 nM, Kb = 0.04 nM; 5-HT7 Ki = 451 nM, Kb = 460 nM) with additional inhibitory activity against PDE4B/PDE7A (PDE4B IC50 = 80.4 μM; PDE7A IC50 = 151.3 μM) . Its antidepressant-like effect surpasses that of the reference agent, escitalopram.
Smiles
O(C)C1=C(C=CC=C1)N2CCN(CCCCC(NC3=CC=C(C(C)C)C=C3)=O)CC2
Molecular Formula
C25H35N3O2
Molecular Weight
409.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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