PDE4B/7A-IN-1

CAT: 0931-MF-0139983-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0139983-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2511632-25-8
Target
5-HT Receptor|||Others|||PDE
Related Pathways
Metabolism|||Others|||Neuroscience|||GPCR/G Protein
Bioactivity
Compound 22, a 5-hydroxynitrile rubber 7 receptor antagonist (5-HT1A Ki=8 nm, Kb=0.04 nm; 5-nitrile rubber 7K I=451 nm, Kb=460 nm), exhibits inhibitory activity against PDE4B/PDE7A (PDE4B IC50=80.4 ?M; PDE7A IC50=151.3 ?M) . It demonstrates significant passive biofilm penetration capabilities and high metabolic stability in vitro. Pharmacological assessment has revealed precognitive and antidepressant effects in rat behavioral tests, highlighting its potential therapeutic applications.
Smiles
O(C)C1=C(C=CC=C1)N2CCN(CCCC(NC3=CC(C(C)(C)C)=CC=C3O)=O)CC2
Molecular Formula
C25H35N3O3
Molecular Weight
425.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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