PDE4B/7A-IN-1

• Target :

  5-HT Receptor|||Others|||PDE

• Related Pathways :

  Metabolism|||Others|||Neuroscience|||GPCR/G Protein

• Bioactivity :

  Compound 22, a 5-hydroxynitrile rubber 7 receptor antagonist (5-HT1A Ki=8 nm, Kb=0.04 nm; 5-nitrile rubber 7K I=451 nm, Kb=460 nm), exhibits inhibitory activity against PDE4B/PDE7A (PDE4B IC50=80.4 ?M; PDE7A IC50=151.3 ?M) . It demonstrates significant passive biofilm penetration capabilities and high metabolic stability in vitro. Pharmacological assessment has revealed precognitive and antidepressant effects in rat behavioral tests, highlighting its potential therapeutic applications.

• Smiles :

  O(C)C1=C(C=CC=C1)N2CCN(CCCC(NC3=CC(C(C)(C)C)=CC=C3O)=O)CC2

• Molecular Formula :

  C25H35N3O3

• Molecular Weight :

  425.56

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2511632-25-8