PDE4B/7A-IN-1

• Target:

  5-HT Receptor|||Others|||PDE

• Related Pathways:

  Metabolism|||Others|||Neuroscience|||GPCR/G Protein

• Bioactivity:

  Compound 22, a 5-hydroxynitrile rubber 7 receptor antagonist (5-HT1A Ki=8 nm, Kb=0.04 nm; 5-nitrile rubber 7K I=451 nm, Kb=460 nm), exhibits inhibitory activity against PDE4B/PDE7A (PDE4B IC50=80.4 ?M; PDE7A IC50=151.3 ?M) . It demonstrates significant passive biofilm penetration capabilities and high metabolic stability in vitro. Pharmacological assessment has revealed precognitive and antidepressant effects in rat behavioral tests, highlighting its potential therapeutic applications.

• Smiles:

  O (C) C1=C (C=CC=C1) N2CCN (CCCC (NC3=CC (C (C) (C) C) =CC=C3O) =O) CC2

• Molecular Formula:

  C25H35N3O3

• Molecular Weight:

  425.56

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2511632-25-8