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CDK9-IN-37

CAT: 0931-T207214-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207214-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
CDK
Related Pathways
Cell Cycle/Checkpoint
Bioactivity
CDK9-IN-37 (Compound 24) is a CDK9 inhibitor with high selectivity, demonstrating an EC50 of 5.5 nM and minimal inhibition of other CDK subtypes. It shows significant antiproliferative activity against acute myeloid leukemia cells MOLM-13, with an IC50 of 0.034 μM. CDK9-IN-37 suppresses CDK9 signaling, reducing RNAP II CTD (Ser2) phosphorylation, downregulating the anti-apoptotic protein McI-1, inducing apoptosis, and causing cell cycle arrest at the G2/M phase. This compound is applicable in the research of acute myeloid leukemia (AML) .
Molecular Formula
C20H19FN2O4S2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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