Antifolate agent 1

• Target :

  Antifolate

• Related Pathways :

  Cell Cycle/Checkpoint

• Bioactivity :

  Antifolateagent 1 (Compound 1) is an antifolate agent featuring a single-carbon bridge. It lacks RFC transport, shows no affinity for FR? and FR?, and exhibits no GARFTase inhibition activity. Antifolateagent 1 serves as a negative control in the development of folate receptor-targeted antifolate agents.

• Smiles :

  O=C1C2=C(NC(CC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=C2)NC(N)=N1

• Molecular Formula :

  C19H19N5O6

• Molecular Weight :

  413.38

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  518063-75-7