RK-0080552

• Target:

  Histone Methyltransferase

• Related Pathways:

  Chromatin/Epigenetic

• Bioactivity:

  RK-0080552 (RK-552) is an inhibitor of the NSD2 histone methyltransferase. It demonstrates significant cytotoxicity against multiple myeloma (MM) cells harboring the t (4;14) translocation. This compound suppresses the IRF4 gene and decreases the dimethylation of histone H3 at lysine 36. RK-0080552 holds promise for research in hematologic malignancies.

• Smiles:

  O=C1C=2N=NC (=NC2C=3C=CC=CC13) C4=NON=C4N

• Molecular Formula:

  C12H6N6O2

• Molecular Weight:

  266.215

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  313527-11-6