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S118

CAT: 0931-T206935-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206935-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2677041-36-8
Target
Wnt/beta-catenin
Related Pathways
Stem Cells, Cytoskeletal Signaling
Bioactivity
S118 is an orally active inhibitor of the sphingosine-1-phosphate receptor 2 (S1P2 receptor) . It prevents the binding of the S1P2 receptor to dapper1 (Dpr1), reduces the accumulation of β-catenin, and blocks the nuclear translocation of the S1P2 receptor. This process inhibits inflammation, fibrosis, and epithelial-mesenchymal transition (EMT), thereby exhibiting anti-idiopathic pulmonary fibrosis (IPF) activity. S118 is considered promising for research in idiopathic pulmonary fibrosis.
Smiles
O=C(NNC=1N=C2C(C=NN2C)=C(C1)C=3C=CC(F)=CC3)NC=4C=C(Cl)N=C(Cl)C4
Molecular Formula
C19H14Cl2FN7O
Molecular Weight
446.265
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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