S118

• Target :

  Wnt/beta-catenin

• Related Pathways :

  Stem Cells|||Cytoskeletal Signaling

• Bioactivity :

  S118 is an orally active inhibitor of the sphingosine-1-phosphate receptor 2 (S1P2 receptor) . It prevents the binding of the S1P2 receptor to dapper1 (Dpr1), reduces the accumulation of ?-catenin, and blocks the nuclear translocation of the S1P2 receptor. This process inhibits inflammation, fibrosis, and epithelial-mesenchymal transition (EMT), thereby exhibiting anti-idiopathic pulmonary fibrosis (IPF) activity. S118 is considered promising for research in idiopathic pulmonary fibrosis.

• Smiles :

  O=C(NNC=1N=C2C(C=NN2C)=C(C1)C=3C=CC(F)=CC3)NC=4C=C(Cl)N=C(Cl)C4

• Molecular Formula :

  C19H14Cl2FN7O

• Molecular Weight :

  446.265

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2677041-36-8