Synuclein-β (S118) polyclonal antibody

• Background :

  The synuclein family members, including α-synuclein (also designated NACP for non-β amyloid component) and β-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. α-synuclein is localized to neuronal cell bodies and synapses. α-synuclein was first identified as a component of Alzheimer’s disease amyloid plaques. Abnormal platelet function in Alzheimer’s disease has been demonstrated. During megakaryocytic differentiation α-synuclein was found to be upregulated, while β-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of α-synuclein has been found in patients with early onset Parkinson’s disease.

• Structure Composition :

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative :

  Beta-synuclein; SNCB; Synuclein β; β-Synuclein

• Swiss Prot :

  Q16143

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Synthetic peptide, corresponding to amino acids 82-140 of Human Synuclein-β.

• Conjugation :

  Unconjugated

• Applications :

  WB IHC IF

• Dilution :

  WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodified

• Molecular Weight :

  ~ 19 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  Synuclein β (S118) polyclonal antibody detects endogenous levels of Synuclein β protein.

• Applications Notes :

  Western blot (WB) analysis of Synuclein-β (S118) pAb at 1:500 dilution Lane1:The Brain tissue lysate of Mouse (20ug) Lane2:The Brain tissue lysate of Rat (40ug)

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4