S119-8

• Target:

  Influenza Virus

• Related Pathways:

  Microbiology/Virology

• Purity:

  0.9983

• Bioactivity:

  RN-18 antagonizes Vif function and inhibits HIV-1 replication only in the presence of A3G. RN-18 increases cellular A3G levels in a Vif-dependent manner and increases A3G incorporation into virions without inhibiting general proteasome-mediated protein degradation. RN-18 enhances Vif degradation only in the presence of A3G, reduces viral infectivity by increasing A3G incorporation into virions and enhances cytidine deamination of the viral genome.

• Smiles:

  CC(C)(C)c1ccc(cc1)C(=O)Nc1ccc(Nc2ccccc2)cc1

• Molecular Formula:

  C23H24N2O

• Molecular Weight:

  344.45

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  443639-96-1