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S118

CAT: 0804-HY-176057Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176057Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
S118 is an orally active sphingosine-1-phosphate receptor 2 (S1P2 receptor) inhibitor. S118 prevents the binding of the S1P2 receptor to dapper1 (Dpr1), reduces the accumulation of β-catenin and blocks the nuclear translocation of the S1P2 receptor, thereby inhibiting inflammation, fibrosis, and epithelial-mesenchymal transition (EMT) and exerting anti-idiopathic pulmonary fibrosis (IPF) activity. S118 is promising for research of idiopathic pulmonary fibrosis[1].
CAS Number
2677041-36-8
UNSPSC
12352005
Target
β-catenin
Related Pathways
Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
CN1N=CC2=C1N=C(C=C2C3=CC=C(C=C3)F)NNC(NC4=CC(Cl)=NC(Cl)=C4)=O
Molecular Formula
C19H14Cl2FN7O
Molecular Weight
446.27
References & Citations
[1]Mu SY, et al. Inhibition of sphingosine-1-phosphate receptor-2 attenuates idiopathic pulmonary fibrosis by preventing its binding to dapper1 in bronchial epithelial cells. Br J Pharmacol. 2025 Apr 13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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