S118

• Description :

  S118 is an orally active sphingosine-1-phosphate receptor 2 (S1P2 receptor) inhibitor. S118 prevents the binding of the S1P2 receptor to dapper1 (Dpr1), reduces the accumulation of β-catenin and blocks the nuclear translocation of the S1P2 receptor, thereby inhibiting inflammation, fibrosis, and epithelial-mesenchymal transition (EMT) and exerting anti-idiopathic pulmonary fibrosis (IPF) activity. S118 is promising for research of idiopathic pulmonary fibrosis[1].

• UNSPSC :

  12352005

• Target :

  β-catenin

• Related Pathways :

  Stem Cell/Wnt

• Field of Research :

  Inflammation/Immunology

• Smiles :

  CN1N=CC2=C1N=C(C=C2C3=CC=C(C=C3)F)NNC(NC4=CC(Cl)=NC(Cl)=C4)=O

• Molecular Formula :

  C19H14Cl2FN7O

• Molecular Weight :

  446.27

• References & Citations :

  [1]Mu SY, et al. Inhibition of sphingosine-1-phosphate receptor-2 attenuates idiopathic pulmonary fibrosis by preventing its binding to dapper1 in bronchial epithelial cells. Br J Pharmacol. 2025 Apr 13.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2677041-36-8]