TGF?RI-IN-7

• Target:

  TGF-beta/Smad

• Related Pathways:

  Stem Cells

• Bioactivity:

  TGF?RI-IN-7 (compound 16W) is a potent inhibitor of TGF?RI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGF?RI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.

• Smiles:

  CN(C)CCN1C=C(C=N1)C2=CC3=NC=CC(=C3C=C2)OC4=CN(N=C4C5CCOCC5)C6CC6

• Molecular Formula:

  C27H32N6O2

• Molecular Weight:

  472.582

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C