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TGFβRI-IN-7

CAT: 0931-T206870-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206870-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
TGF-beta/Smad
Related Pathways
Stem Cells
Bioactivity
TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.
Smiles
CN(C)CCN1C=C(C=N1)C2=CC3=NC=CC(=C3C=C2)OC4=CN(N=C4C5CCOCC5)C6CC6
Molecular Formula
C27H32N6O2
Molecular Weight
472.582
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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