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TCIP3

CAT: 0931-T206850-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206850-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3067681-36-8
Target
Molecular Glues, Bcl-6, Histone Acetyltransferase
Related Pathways
PROTAC, Immunology/Inflammation, Chromatin/Epigenetic
Bioactivity
TCIP3 is a bivalent molecular glue (molecular glue) that can simultaneously bind to both p300/CBP and BCL6. It redirects p300 and CBP to activate programmed cell death genes, which are typically repressed by the oncogenic driver BCL6. TCIP3 is useful for studying diffuse large B-cell lymphoma (DLBCL) and is not toxic to untransformed tonsil lymphocytes or fibroblasts.
Smiles
O=C(NC)N1CC=2C(=NN(C2CC1)C3CCN(C(=O)CCN4CCN(C(=O)C5CCN(C6=NC=C(Cl)C(=N6)NC=7C=C(OC)C8=C(C=C(OCC(=O)NC)C(=O)N8C)C7)CC5)CC4)CC3)N9C=%10C=C(C(=CC%10CCC9)C=%11C=NN(C%11)C)C(F)F
Molecular Formula
C58H71ClF2N16O7
Molecular Weight
1177.74
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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