TCIP3

CAT: 0804-HY-173552-02Size: 1 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-173552-02Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

TCIP3 is a bivalent molecular glue with with dual binding to p300/CBP and BCL6. TCIP3 redirects p300 and CBP to activate programmed cell death genes normally repressed by the oncogenic driver, BCL6. TCIP3 can be used for the study of diffuse large B cell lymphomas (DLBCLs) . TCIP3 exhibits no toxicity in non-transformed tonsillar lymphocytes or fibroblasts[1].

CAS Number

3067681-36-8

UNSPSC

12352005

Target

BCL6; Histone Acetyltransferase; Molecular Glues

Related Pathways

Epigenetics; Immunology/Inflammation; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.30

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1CC2=C(CC1)N(C3CCN(CC3)C(CCN4CCN(CC4)C(C5CCN(CC5)C6=NC=C(C(NC7=CC(C=C(C(N8C)=O)OCC(NC)=O)=C8C(OC)=C7)=N6)Cl)=O)=O)N=C2N9C%10=C(CCC9)C=C(C%11=CN(C)N=C%11)C(C(F)F)=C%10)NC

Molecular Formula

C58H71ClF2N16O7

Molecular Weight

1177.74

References & Citations

[1]Nix MN, et al. A Bivalent Molecular Glue Linking Lysine Acetyltransferases to Oncogene-induced Cell Death. bioRxiv [Preprint]. 2025 Mar 17:2025.03.14.643404.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

1-[1-[3-[4-[1-[5-chloro-4-[[8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxoquinolin-6-yl]amino]pyrimidin-2-yl]piperidine-4-carbonyl]piperazin-1-yl]propanoyl]piperidin-4-yl]-3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-N-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide

CAS Number	3067681-36-8
PubChem CID	176131181
IUPAC Name	1-[1-[3-[4-[1-[5-chloro-4-[[8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxoquinolin-6-yl]amino]pyrimidin-2-yl]piperidine-4-carbonyl]piperazin-1-yl]propanoyl]piperidin-4-yl]-3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-N-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
Molecular Formula	C58H71ClF2N16O7
Molecular Weight	1177.7
XLogP	4.1
Topological Polar Surface Area	224
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	17
Rotatable Bond Count	15
Heavy Atom Count	84
Formal Charge	0
Complexity	2330

SMILES

CNC(=O)COC1=CC2=CC(=CC(=C2N(C1=O)C)OC)NC3=NC(=NC=C3Cl)N4CCC(CC4)C(=O)N5CCN(CC5)CCC(=O)N6CCC(CC6)N7C8=C(CN(CC8)C(=O)NC)C(=N7)N9CCCC1=CC(=C(C=C19)C(F)F)C1=CN(N=C1)C

InChI

InChI=1S/C58H71ClF2N16O7/c1-62-49(78)34-84-48-27-37-25-39(28-47(83-5)51(37)70(4)56(48)81)66-53-44(59)31-64-57(67-53)74-16-8-35(9-17-74)55(80)73-23-21-71(22-24-73)15-13-50(79)72-18-10-40(11-19-72)77-45-12-20-75(58(82)63-2)33-43(45)54(68-77)76-14-6-7-36-26-41(38-30-65-69(3)32-38)42(52(60)61)29-46(36)76/h25-32,35,40,52H,6-24,33-34H2,1-5H3,(H,62,78)(H,63,82)(H,64,66,67)

InChIKey

NHWQUQINMUWILV-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 3067681-36-8

CID: 176131181

Formula: C58H71ClF2N16O7

MW: 1177.7

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	1177.7
XLogP3	4.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	17
Rotatable Bond Count	15
Exact Mass	1176.5348227
Monoisotopic Mass	1176.5348227
Topological Polar Surface Area	224 Å²
Heavy Atom Count	84
Formal Charge	0
Complexity	2330
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-169244-01	CDK-TCIP1
HY-169245-01	CDK-TCIP2
HY-156531	TCIP 1
HY-173364-01	EB-TCIP

Alternative Products

Catalog	Name
GTR19258243-01	TCIP3

TCIP3

Chemical Information

Related Products

Alternative Products

Popular Products