TCIP 1

CAT: 0931-T79801-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T79801-01Size:25 mg
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Target
Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic
Bioactivity
TCIP 1 is a small molecule in the category of transcriptional/epigenetic covalent inhibitor probes (TCIPs) that forms covalent bonds with molecules targeting BCL6 and BRD4. This compound facilitates cell death gene expression by directing endogenous cancer drivers or transcription factors to the promoters of these genes. Additionally, TCIP 1 exhibits a gain-of-function mechanism, displaying both cell and tissue specificity, and it establishes a ternary complex with BCL6 and BRD4. It counteracts BCL6's inhibitory effect on apoptosis gene expression, leading to the activation of apoptosis. Furthermore, TCIP 1 markedly suppresses MYC oncogene expression and curtails the proliferation of diffuse large B-cell lymphoma (DLBCL) [1].
Smiles
CNC(COC1=CC2=C(C(OC)=CC(NC3=NC(N4CCC(C(NCCCCCCCNC(C[C@@H]5N=C(C6=CC=C(Cl)C=C6)C7=C(SC(C)=C7C)N8C(C)=NN=C58)=O)=O)CC4)=NC=C3)=C2)N(C)C1=O)=O
Molecular Formula
C50H58Cl2N12O6S
Molecular Weight
1026.04
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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