DPP8/9-IN-1

• Target:

  Proteasome

• Related Pathways:

  Ubiquitination|||Proteases/Proteasome

• Bioactivity:

  DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C