NLRP3-IN-76

CAT: 0931-MF-0114712-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0114712-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Interleukin|||NF-?B|||NOD-like Receptor (NLR) |||NO Synthase
Related Pathways
Immunology/Inflammation|||NF-?B
Bioactivity
NLRP3-IN-76 is an orally active NLRP3 inhibitor that suppresses the production of NO and reduces the mRNA levels of pro-inflammatory cytokines (iNOS, IL-6, IL-1?, and TNF?) . It exerts anti-inflammatory effects by inhibiting the activation of the NLRP3 inflammasome and the NF-?B signaling pathway. Furthermore, NLRP3-IN-76 can ameliorate DSS-induced colitis and is applicable for studying inflammatory bowel disease (IBD) .
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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