NLRP3-IN-82

• Target:

  NOD-like Receptor (NLR)

• Related Pathways:

  Immunology/Inflammation

• Bioactivity:

  NLRP3-IN-82 (Compound 2b) is an NLRP3 inhibitor that significantly suppresses IL-1? release in HMDM cells with an IC50 of less than 5 nM. This compound is applicable for research into neurological disorders such as Alzheimer's disease, inflammatory conditions like inflammatory bowel disease, and metabolic disorders such as obesity.

• Smiles:

  CN1C[C@]2(N(C=3C=4N(C(=NN3)C5=C(O)C=C(Cl)C(C)=C5)C=CN4)CC[C@]2(CC1)[H])[H]

• Molecular Formula:

  C20H23ClN6O

• Molecular Weight:

  398.89

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3091347-92-8