TDI-012804

• Target:

  PARP

• Related Pathways:

  DNA Damage/DNA Repair|||Chromatin/Epigenetic

• Bioactivity:

  TDI-012804 is a TNKS2 inhibitor that selectively inhibits endogenous TNKS2 protein within cells. It enhances the expression of AXIN1 protein in Tnks1 heterozygous (Tnks1HET) and knockout (Tnks1KO) cells. TDI-012804 suppresses the proliferation of ApcQ1405X/Tnks1KO organoids with an EC50 of 59.1 nM and exhibits selective toxicity towards Tnks1KO AKP-G12D and AKP-G13D organoids.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C