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TDI-012804

CAT: 0931-T206709-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206709-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
PARP
Related Pathways
DNA Damage/DNA Repair, Chromatin/Epigenetic
Bioactivity
TDI-012804 is a TNKS2 inhibitor that selectively inhibits endogenous TNKS2 protein within cells. It enhances the expression of AXIN1 protein in Tnks1 heterozygous (Tnks1HET) and knockout (Tnks1KO) cells. TDI-012804 suppresses the proliferation of ApcQ1405X/Tnks1KO organoids with an EC50 of 59.1 nM and exhibits selective toxicity towards Tnks1KO AKP-G12D and AKP-G13D organoids.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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