PDE2 inhibitor 6

CAT: 0931-T206498-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T206498-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2097493-39-3

Target

PDE, iGluR

Related Pathways

Metabolism, Membrane transporter/Ion channel, Neuroscience

Bioactivity

PDE2 inhibitor6 (Compound 1) is an orally active phosphodiesterase (PDE) inhibitor, effectively inhibiting PDE2A, PDE3B, and PDE10A2 with IC50 values of 0.95 nM, 6.17 μM (pIC50=5.21), and 87.1 nM (pIC50=7.06), respectively. It modulates AMPA receptor activity, enhances synaptic plasticity, and improves learning and memory in rat models. Furthermore, PDE2 inhibitor6 possesses blood-brain barrier permeability.

Smiles

C[C@H]1[C@H](C=2N3C(N=C(C(F)F)C2)=NC=N3)CN(C(=O)C=4C=C(C)N=C(C)C4)CC1

Molecular Formula

C20H22F2N6O

Molecular Weight

400.425

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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GTR19258541-01	PDE2 inhibitor 6
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PDE2 inhibitor 6

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