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SKP-451

CAT: 0931-T206322-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T206322-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
181137-41-7
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Bioactivity
SKP-451 is an ATP-sensitive potassium (K+) channel agonist. It activates ATP-sensitive K+ channels, promoting the efflux of K+, leading to membrane hyperpolarization and inhibiting Ca2+ influx, which results in the relaxation of vascular smooth muscle. SKP-451 relaxes canine coronary arteries, rabbit basilar arteries, and vertebral arteries. Additionally, SKP-451 lowers mean arterial blood pressure in conscious spontaneously hypertensive rats (SHR) . It holds potential for cardiovascular disease research.
Smiles
N(=O)(=O)C=1C=C2C(=C[C@](C)(OC2=CC1)[C@@H]3OCCO3)N4C(=O)CCC4
Molecular Formula
C17H18N2O6
Molecular Weight
346.335
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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