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SKP-451

CAT: 0804-HY-171469Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-171469Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SKP-451 is an ATP-sensitive potassium (K+) channel agonist. SKP-451 activates the ATP-sensitive K+ channels, promotes the efflux of K+, causes membrane hyperpolarization, and inhibits the influx of Ca2+, thereby relaxing the vascular smooth muscle. SKP-451 relaxs the canine coronary artery, rabbit basilar artery, and vertebral artery. SKP-451 also reduces the mean arterial blood pressure of conscious spontaneously hypertensive rats (SHR) . SKP-451 is promising for research of cardiovascular diseases[1].
CAS Number
[181137-41-7]
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Smiles
[O-][N+](C1=CC=C2O[C@](C)(C3OCCO3)C=C(N4C(CCC4)=O)C2=C1)=O
Molecular Formula
C17H18N2O6
Molecular Weight
346.33
References & Citations
[1]Hong KW, et al. Pharmacological profiles of SKP-450 and its family, a K+ channel opener, in comparison with levcromakalim. Pharmacol Res. 1998 Sep;38 (3) :191-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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