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CSN5-IN-2

CAT: 0931-T206319-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206319-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
DNA/RNA Synthesis, PD-1/PD-L1
Related Pathways
Immunology/Inflammation, DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Apoptosis
Bioactivity
CSN5-IN-2 (Compound 31) is a CSN5 inhibitor with an IC50 of 0.36 μM. It increases Cullin 1 neddylation levels in cancer cells and downregulates the expression of RAD51 and PD-L1. CSN5-IN-2 exhibits antitumor activity, which is enhanced when used in combination with Talazoparib.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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