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BF-170

CAT: 0931-T205480-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T205480-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
22191-97-5
Target
Microtubule Associated
Related Pathways
Cytoskeletal Signaling
Bioactivity
BF-170 is a selective tau fiber-binding agent with an EC50 of 221 nM. It demonstrates excellent blood-brain barrier penetration, reaching a concentration of 9.1% ID/g in brain tissue 2 minutes after intravenous injection in mice (with a clearance rate of 0.25% ID/g at 30 minutes) . BF-170 can serve as a probe for imaging tau protein pathology in Alzheimer's disease (AD) . It plays a significant role in early-stage Alzheimer's disease studies and holds promise for imaging research in tau-related neurodegenerative diseases.
Smiles
N=1C=2C=CC=CC2C=CC1C=3C=CC(N)=CC3
Molecular Formula
C15H12N2
Molecular Weight
220.269
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

2-(4-Aminophenyl)quinoline

used for imaging tau protein; structure in first source

CAS Number22191-97-5
PubChem CID297284
IUPAC Name4-quinolin-2-ylaniline
Molecular FormulaC15H12N2
Molecular Weight220.27
XLogP3.2
Topological Polar Surface Area38.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count17
Formal Charge0
Complexity245
SMILES
C1=CC=C2C(=C1)C=CC(=N2)C3=CC=C(C=C3)N
InChI
InChI=1S/C15H12N2/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15/h1-10H,16H2
InChIKey
PWLMSCCFNGGPGM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(4-Aminophenyl)quinoline
CAS: 22191-97-5
CID: 297284
Formula: C15H12N2
MW: 220.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight220.27
XLogP33.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass220.100048391
Monoisotopic Mass220.100048391
Topological Polar Surface Area38.9 Ų
Heavy Atom Count17
Formal Charge0
Complexity245
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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