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Keap1-IN-1

CAT: 0013-GTR19250045-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19250045-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Keap1-IN-1 (Compound 27) is a covalent Keap1 inhibitor that selectively targets the Cys151 residue, disrupting the Keap1-Nrf2 interaction to activate the Nrf2/ARE pathway. It induces NQO1 expression (EC50 = 160 nM) and demonstrates cytotoxicity in U2OS cells (EC50 = 527 nM), making it a valuable chemical probe for studying oxidative stress responses in cancer and neurodegenerative disease research.
Field of Research
Cancer Biology, Immunology & Inflammation, Metabolism Research
Smiles
CCP1 (=O) CCN (CC1) C2=C (N=C (S2) S (=O) (=O) CC) S (=O) (=O) C3=C (C (=CC=C3) Cl) Cl
Molecular Formula
C17H21Cl2N2O5PS3
Molecular Weight
531.434
Storage Conditions
-20°C
Notes
For research use only.

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