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SIRT6-IN-3

CAT: 0931-T79689-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T79689-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3023471-40-8
Target
Sirtuin
Related Pathways
DNA Damage/DNA Repair, Chromatin/Epigenetic
Bioactivity
SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts apoptosis. It enhances the responsiveness of cancer cells to gemcitabine by obstructing the DNA damage repair pathway, thus serving as a valuable tool in pancreatic cancer research [1].
Smiles
[Br-].Cl.BrC=1C=C(NC1Br)C2=NC=CC3=C2N=CN3CCCCCCSC(N(C)C)=[N+](C)C
Molecular Formula
C21H30Br3ClN6S
Molecular Weight
673.73
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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