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SAL-0010042

CAT: 0931-T204533-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204533-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
521298-46-4
Target
Parasite, PDE
Related Pathways
Metabolism, Microbiology/Virology
Bioactivity
SAL-0010042 is an inhibitor of Plasmodium phosphodiesterase β (PDEβ), effectively blocking the hydrolysis of cAMP and cGMP in gametocytes with an IC50 of 48.9 nM, thereby activating PKG and inhibiting the growth and development of Plasmodium (IC50s for 3D7 and Dd2 are 142 nM and 218 nM, respectively) . It also inhibits hPDE5 and hPDE6 with IC50 values of 632 nM and 73 nM, respectively.
Smiles
O=C1N=C(NC=2C(=NNC12)C(C)C)CC=3C=CC=CC3F
Molecular Formula
C15H15FN4O
Molecular Weight
286.304
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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