MLK3-IN-1

• Target:

  FAK|||MLK

• Related Pathways:

  Cytoskeletal Signaling|||Angiogenesis|||MAPK|||Tyrosine Kinase/Adaptors

• Bioactivity:

  MLK3-IN-1 (Compound 37) is a selective inhibitor of mixed-lineage kinase 3 (MLK3) with an IC50 of less than 1 nM. It also inhibits FAK with an IC50 of 15.5 ?M. In both murine and human liver microsomes, MLK3-IN-1 demonstrates excellent metabolic stability.

• Smiles:

  CS (=O) (=O) C1=CC=CC (=C1) CNC2=NC (=NC=C2C (F) (F) F) NC3=CC=C (C=C3) C (F) (F) F

• Molecular Formula:

  C20H16F6N4O2S

• Molecular Weight:

  490.422

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C