MLK3-IN-1

CAT: 0931-T204487-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T204487-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

FAK, MLK

Related Pathways

Cytoskeletal Signaling, Angiogenesis, MAPK, Tyrosine Kinase/Adaptors

Bioactivity

MLK3-IN-1 (Compound 37) is a selective inhibitor of mixed-lineage kinase 3 (MLK3) with an IC50 of less than 1 nM. It also inhibits FAK with an IC50 of 15.5 μM. In both murine and human liver microsomes, MLK3-IN-1 demonstrates excellent metabolic stability.

Smiles

CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC=C(C=C3)C(F)(F)F

Molecular Formula

C20H16F6N4O2S

Molecular Weight

490.422

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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MLK3-IN-1

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