MLK3-IN-1

• Target :

  FAK|||MLK

• Related Pathways :

  Cytoskeletal Signaling|||Angiogenesis|||MAPK|||Tyrosine Kinase/Adaptors

• Bioactivity :

  MLK3-IN-1 (Compound 37) is a selective inhibitor of mixed-lineage kinase 3 (MLK3) with an IC50 of less than 1 nM. It also inhibits FAK with an IC50 of 15.5 ?M. In both murine and human liver microsomes, MLK3-IN-1 demonstrates excellent metabolic stability.

• Smiles :

  CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC=C(C=C3)C(F)(F)F

• Molecular Formula :

  C20H16F6N4O2S

• Molecular Weight :

  490.422

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C