MLK-IN-1

• CAS Number :

  1627729-62-7

• Target :

  MLK

• Related Pathways :

  MAPK

• Purity :

  0.9974

• Bioactivity :

  MLK-IN-1 is a potent and selective mixed-lineage kinase 3 (MLK-3) inhibitor, showing excellent brain penetration and high specificity for MLK-3. MLK-IN-1 at 100 nM supports sustained axonogenesis in cultures challenged with HIV-1 Tat-activated microglia and protects neuronal cells from Tat-induced damage, establishing it as a valuable probe for neuroinflammation and neurodegeneration research.

• Smiles :

  N=1C=C(C=2SC=3C(OC)=CC=CC3C2)N4N=C(C=CC14)NC5=CC=C(OC)C(OC)=C5

• Molecular Formula :

  C23H20N4O3S

• Molecular Weight :

  432.5

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C