MLK-IN-1

• Target:

  MLK

• Related Pathways:

  MAPK

• Purity:

  0.9974

• Bioactivity:

  MLK-IN-1 is a potent and selective mixed-lineage kinase 3 (MLK-3) inhibitor, showing excellent brain penetration and high specificity for MLK-3. MLK-IN-1 at 100 nM supports sustained axonogenesis in cultures challenged with HIV-1 Tat-activated microglia and protects neuronal cells from Tat-induced damage, establishing it as a valuable probe for neuroinflammation and neurodegeneration research.

• Smiles:

  N=1C=C (C=2SC=3C (OC) =CC=CC3C2) N4N=C (C=CC14) NC5=CC=C (OC) C (OC) =C5

• Molecular Formula:

  C23H20N4O3S

• Molecular Weight:

  432.5

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1627729-62-7