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RD-23

CAT: 0931-T204442-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204442-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3053537-06-4
Target
Apoptosis, PROTACs, c-RET
Related Pathways
PROTAC, Tyrosine Kinase/Adaptors, Apoptosis
Bioactivity
RD-23 is an orally active and selective RET PROTAC degrader. It facilitates the ubiquitination and degradation of the RETG810C mutant with a DC50 value of 11.7 nM. Additionally, RD-23 inhibits the activation of downstream Shc signaling and induces apoptosis (Apoptosis) . It is useful for studying RET-related cancers.
Smiles
N#CC=1C=NN2C=C(C=C(C=3C=NC(=CC3)N4CC5N(CC6=CN=C(OC)C=C6)C(C4)C5)C12)N7CCC(N8CCN(CC8)CCCC#CC9=CC=CC=%10C(=O)N(CC9%10)C%11C(=O)NC(=O)CC%11)CC7
Molecular Formula
C52H56N12O4
Molecular Weight
913.079
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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