RD-23

• Target :

  Apoptosis|||PROTACs|||c-RET

• Related Pathways :

  PROTAC|||Tyrosine Kinase/Adaptors|||Apoptosis

• Bioactivity :

  RD-23 is an orally active and selective RET PROTAC degrader. It facilitates the ubiquitination and degradation of the RETG810C mutant with a DC50 value of 11.7 nM. Additionally, RD-23 inhibits the activation of downstream Shc signaling and induces apoptosis (Apoptosis) . It is useful for studying RET-related cancers.

• Smiles :

  N#CC=1C=NN2C=C(C=C(C=3C=NC(=CC3)N4CC5N(CC6=CN=C(OC)C=C6)C(C4)C5)C12)N7CCC(N8CCN(CC8)CCCC#CC9=CC=CC=%10C(=O)N(CC9%10)C%11C(=O)NC(=O)CC%11)CC7

• Molecular Formula :

  C52H56N12O4

• Molecular Weight :

  913.079

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  3053537-06-4