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119-23

CAT: 0931-T201890-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T201890-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2953044-98-7
Bioactivity
119-23 is an ionizable cationic lipid frequently utilized in the preparation of lipid nanoparticles (LNPs) for in vivo mRNA delivery. Lipid nanoparticles that include 119-23 and encapsulate mRNA reporter molecules demonstrate a higher transfection efficiency in mouse muscle compared to LNPs containing SM-102 or DLin-MC3-DMA. Additionally, the accumulation of 119-23-containing LNPs in immune cells within the liver and spleen of mice is significantly greater than that of LNPs with SM-102. Furthermore, LNPs containing 119-23 and encoding human erythropoietin (hEPO) mRNA can elevate serum hEPO levels in mice.
Smiles
N(C(C(N(C(CCCCCCC/C=C\CCCCCCCC)=O)CCCN(C)C)CCCCCOC(CCCCCCC/C=C\CCCCCCCC)=O)=O)C12CC3CC(C1)CC(C2)C3
Molecular Formula
C58H105N3O4
Molecular Weight
908.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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